Secretory reactions of cultured hypophyseal growth hormone-producing adenoma cells to somatoliberin and somatostatin

@article{Komolov2006SecretoryRO,
  title={Secretory reactions of cultured hypophyseal growth hormone-producing adenoma cells to somatoliberin and somatostatin},
  author={I. S. Komolov and Alexander Bulatov and T. A. Osipova and G. P. Elizarova and S. Yu. Serpukhovitin and S. Yu. Kasumova},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2006},
  volume={123},
  pages={279-282}
}
Somatoliberin stimulates secretion of growth hormone and has no effect on secretion of prolactin in primary cultures of hypophyseal adenoma cells obtained from acromegalic patients. A short-term contact of the cells with somatostatin inhibits secretion of growth hormone, while a long-term contact with this hormone inhibits prolactin production. Somatoliberin abolishes the inhibitory effect of somatostatin on the growth hormone secretion and at high concentrations stimulates it.