Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix.

@article{Tsuji2003SecretoryPC,
  title={Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix.},
  author={Akihiko Tsuji and Kensuke Sakurai and Emi Kiyokage and Takahito Yamazaki and Sizuyo Koide and Kazunori Toida and Kazunori Ishimura and Yoshiko Matsuda},
  journal={Biochimica et biophysica acta},
  year={2003},
  volume={1645 1},
  pages={95-104}
}
PACE4, PC6 and furin are potent subtilisin-like proprotein convertases (SPCs) which are responsible for the activation of transforming growth factor-beta (TGFbeta)-related factors such as bone morphogenetic proteins. Heparan sulfate proteoglycan within the extracellular matrix (ECM) is known to regulate the biological activity of various differentiation factors including TGFbeta-related molecules. PACE4 binds tightly to heparin and its heparin-binding region was found to be a cationic stretch… CONTINUE READING