Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro 

@article{Lisak2012SecretoryPO,
  title={Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
},
  author={Robert P. Lisak and Joyce A Benjamins and Liljana Nedelkoska and Jennifer L Barger and Samia Ragheb and Boli Fan and Nadia Ouamara and Trina A. Johnson and Sathyanath Rajasekharan and Amit Bar-Or},
  journal={Journal of Neuroimmunology},
  year={2012},
  volume={246},
  pages={85-95}
}
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129 Citations

B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro
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Evidence for B cell and Ig contribution to human MS and NMO pathogenesis, pro-inflammatory and regulatory B cell effector functions, impaired B cell immune tolerance, the B cell-fostering microenvironment in the CNS, and B Cell-targeted therapeutic interventions for MS andNMO are discussed.
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This review will describe and summarize pro-inflammatory B cell properties in these three CNS demyelinating disorders, and provide an overview on the emerging concept that B cells or B cell subsets may exert immunologically counterbalancing properties, which may be therapeutically desirable to maintain and foster in inflammatory CNS demYelination.
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The roles of B cells in multiple sclerosis are discussed and the insights gained from the immunological effects of B cell-targeted therapies and autologous haematopoietic stem cell transplantation are considered, as well as the potential for these insights to improve the authors' understanding.
Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis
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Activated astrocytes in the inflamed MS CNS not only promote a B cell fostering environment, but also actively support the ability of B cells to contribute to the propagation of CNS-compartmentalized inflammation, now thought to play key roles in progressive disease.
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