Secretory products of breast cancer cells specifically affect human osteoblastic cells: partial characterization of active factors.

@article{Siwek1997SecretoryPO,
  title={Secretory products of breast cancer cells specifically affect human osteoblastic cells: partial characterization of active factors.},
  author={Brigitte Siwek and M. Lacroix and C de Pollak and Pierre Jacques Marie and Jean Jacques Body},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1997},
  volume={12 4},
  pages={552-60}
}
The pathogenesis of tumor-induced osteolysis (TIO) following breast cancer metastases in bone remains unclear. We postulated that osteoblasts could be target cells for the secretory products of breast cancer cells. We previously showed that serum-free conditioned medium (CM) of the breast cancer cell line MCF-7 inhibits DNA synthesis by 75% of control values in osteoblast-like cells SaOS-2 and that this effect is only in a minor part due to transforming growth factor beta secretion. To… CONTINUE READING

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