Secretory phospholipases A2 are secreted from ciliated cells and increase mucin and eicosanoid secretion from goblet cells.

@article{Tanabe2015SecretoryPA,
  title={Secretory phospholipases A2 are secreted from ciliated cells and increase mucin and eicosanoid secretion from goblet cells.},
  author={Tsuyoshi Tanabe and Tadasuke Shimokawaji and Soichiro Kanoh and Bruce K. Rubin},
  journal={Chest},
  year={2015},
  volume={147 6},
  pages={1599-1609}
}
BACKGROUND Secretory phospholipases A2 (sPLA2) initiate the biosynthesis of eicosanoids, are increased in the airways of people with severe asthma, and induce mucin hypersecretion. We used IL-13-transformed, highly enriched goblet cells and differentiated (ciliary cell-enriched) human bronchial epithelial cell culture to evaluate the relative contribution of ciliated and goblet cells to airway sPLA2 generation and response. We wished to determine the primary source(s) of sPLA2 and leukotrienes… CONTINUE READING
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