Secretory pathway engineering enhances secretion of cellobiohydrolase I from Trichoderma reesei in Saccharomyces cerevisiae.

@article{Xu2014SecretoryPE,
  title={Secretory pathway engineering enhances secretion of cellobiohydrolase I from Trichoderma reesei in Saccharomyces cerevisiae.},
  author={LiLi Xu and Yu Shen and Jin Hou and Bingyin Peng and Hongting Tang and Xiaoming Bao},
  journal={Journal of bioscience and bioengineering},
  year={2014},
  volume={117 1},
  pages={45-52}
}
Improving the cellulase secretion is beneficial for Saccharomyces cerevisiae used in consolidated bioprocessing (CBP) of cellulosic ethanol. In this study, protein secretory pathway, including protein folding, disulfide bond formation, and protein trafficking and sorting, was modified in S. cerevisiae. The effects of these modifications on the secretion of cellobiohydrolase I (Tr-Cel7A) with its native signal peptide from Trichoderma reesei were investigated. The results showed that… CONTINUE READING

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Signal peptide of cellulase

Applied Microbiology and Biotechnology • 2014
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