Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.

@article{Giorgi1989SecretoryPS,
  title={Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.},
  author={Dominique Giorgi and J. P. Bernard and Sylvie Rouquier and J Iovanna and Henri Sarles and Jean Charles Dagorn},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={84 1},
  pages={100-6}
}
The pancreatic stone protein and its secretory form (PSP-S) are inhibitors of CaCO3 crystal growth, possibly involved in the stabilization of pancreatic juice. We have established the structure of PSP-S mRNA and monitored its expression in chronic calcifying pancreatitis (CCP). A cDNA encoding pre-PSP-S has been cloned from a human pancreatic cDNA library. Its nucleotide sequence revealed that it comprised all but the 5' end of PSP-S mRNA, which was obtained by sequencing the first exon of the… CONTINUE READING
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