Secretory leukocyte proteinase inhibitor and elafin are resistant to degradation by MMP-8.

@article{Henry2002SecretoryLP,
  title={Secretory leukocyte proteinase inhibitor and elafin are resistant to degradation by MMP-8.},
  author={Michael T Henry and Kevin McMahon and Christine Costello and Muiris X. FitzGerald and Clare M O'Connor},
  journal={Experimental lung research},
  year={2002},
  volume={28 2},
  pages={85-97}
}
The naturally occurring neutrophil elastase inhibitors, alpha1-proteinase inhibitor (alpha1PI), secretory leukocyte proteinase inhibitor (SLPI), and elafin, are potential therapeutic agents in the treatment of neutrophil-mediated lung disease. However alpha1PI has been shown to be susceptible to inactivation by matrix metalloproteinases (MMPs) released by neutrophils, particularly neutrophil collagenase (MMP-8). The aim of this study was to determine if SLPI and elafin are similarly susceptible… CONTINUE READING