Secretory leukocyte protease inhibitor is associated with MMP-2 and MMP-9 to promote migration and invasion in SNU638 gastric cancer cells.

@article{Choi2011SecretoryLP,
  title={Secretory leukocyte protease inhibitor is associated with MMP-2 and MMP-9 to promote migration and invasion in SNU638 gastric cancer cells.},
  author={Baik-Dong Choi and Soon-Jeong Jeong and Guanlin Wang and Jin-Ju Park and Do-Seon Lim and Byung-Hoon Kim and Yong-Ick Cho and Chang-Seok Kim and Moon-Jin Jeong},
  journal={International journal of molecular medicine},
  year={2011},
  volume={28 4},
  pages={
          527-34
        }
}
Secretory leukocyte protease inhibitor (SLPI) protects tissue from proteases, and promotes cell proliferation and healing during inflammatory response. SLPI is also overexpressed in gastric, lung and ovarian cancers, which accelerates the metastasis of cancer cells. Matrix metalloproteinases-2, -9 (MMP-2 and MMP-9) are overexpressed in high metastatic cancers, and promote the migration of cancer cells through collagen degradation. SLPI and MMP-2, -9 are critical factors in stimulating the… CONTINUE READING
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