Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis

@inproceedings{Habgood2016SecretoryLP,
  title={Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis},
  author={Anthony N Habgood and Amanda L Tatler and Joanne Porte and Sharon M. Wahl and Geoffrey John Laurent and Alison E. John and Simon R Johnson and Gisli Jenkins},
  booktitle={Laboratory Investigation},
  year={2016}
}
Idiopathic pulmonary fibrosis is a progressive, fatal disease with limited treatment options. Protease-mediated transforming growth factor-β (TGF-β) activation has been proposed as a pathogenic mechanism of lung fibrosis. Protease activity in the lung is tightly regulated by protease inhibitors, particularly secretory leukocyte protease inhibitor (SLPI). The bleomycin model of lung fibrosis was used to determine the effect of increased protease activity in the lungs of Slpi−/− mice following… CONTINUE READING
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