Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.

  title={Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.},
  author={Sharon M. Wahl and T B McNeely and Edward N. Janoff and Diane C Shugars and Paul K Worley and Chandra Tucker and Jan Marc Orenstein},
  journal={Oral diseases},
  volume={3 Suppl 1},
Despite the presence of HIV-1 in the oral cavity, transmission of the virus through saliva has not been proven. Consistent with these observations, we recently identified an endogenous 12 kD protein, secretory leukocyte protease inhibitor (SLPI), in saliva which blocks HIV-1 infection in vitro. Whereas other salivary proteins tested were inactive, purified native or recombinant SLPI inhibited HIV-1 infection of human monocytes at 100 ng ml-1. Levels of SLPI quantitated by ELISA in saliva from… CONTINUE READING
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