Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia.

@article{Grobmyer2000SecretoryLP,
  title={Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia.},
  author={Stephen R Grobmyer and Philip S. Barie and Carl F Nathan and M. G. F. Fuortes and Erica Lai-Sze Lin and Stephen F. Lowry and Clifford D. Wright and Michael John Weyant and Lynn J. Hydo and François Reeves and Michael U Shiloh and Ai-ping Ding},
  journal={Critical care medicine},
  year={2000},
  volume={28 5},
  pages={
          1276-82
        }
}
OBJECTIVES To document changes in serum secretory leukocyte protease inhibitor (SLPI) in human sepsis and in experimental endotoxemia in vivo. To compare changes in serum SLPI in human sepsis with changes in interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-alpha. To determine whether or not changes in SLPI correlate with the severity of multiple organ dysfunction syndrome as measured by the maximal multiple organ dysfunction score. Finally, because neutrophils have been implicated in… CONTINUE READING
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