Secretory heat-shock protein as a dendritic cell-targeting molecule: a new strategy to enhance the potency of genetic vaccines

@article{Hauser2004SecretoryHP,
  title={Secretory heat-shock protein as a dendritic cell-targeting molecule: a new strategy to enhance the potency of genetic vaccines},
  author={Hanns Hauser and Li-qin Shen and Q-L Gu and Sabine Krueger and S Chen},
  journal={Gene Therapy},
  year={2004},
  volume={11},
  pages={924-932}
}
DNA vaccines are an appealing strategy for inducing cytotoxic T-lymphocyte and antibody responses against tumor cells as well as infectious agents. Dendritic cells (DCs) play a critical role in inducing immune responses, but their potential is not fully utilized in the DNA vaccine setting since they take up only a minor fraction of the injected DNA. Here we describe a novel DNA vaccination strategy based on the targeting of a modified tumor-associated antigen, the human papilloma virus (HPV… CONTINUE READING

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