Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin.

@article{Gumbiner1981SecretoryGO,
  title={Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin.},
  author={Barry Gumbiner and Regis B. Kelly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 1},
  pages={318-22}
}
The pituitary cell line, AtT-20, synthesizes the precursor to corticotropin (adrenocorticotropic hormone; ACTH) and beta-endorphin and correctly glycosylates and cleaves it to make the mature forms of the hormones before they are secreted. This cell line was used to study the intracellular transport, packaging, and secretion of these hormones. Secretory granules from the cells were isolated by homogenization and differential centrifugation and isopycnic sedimentation on a 2H2O-Ficoll gradient… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
23 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…