Secretory effects of cholecystokinins on the isolated perfused porcine pancreas.

@article{Jensen1981SecretoryEO,
  title={Secretory effects of cholecystokinins on the isolated perfused porcine pancreas.},
  author={Steen Lindk{\ae}r Jensen and Jens F. Rehfeld and Jens Juul Holst and Ole Vagn Nielsen and Jan Fahrenkrug and Ove B Schaffalitzky de Muckadell},
  journal={Acta physiologica Scandinavica},
  year={1981},
  volume={111 3},
  pages={
          225-31
        }
}
Three different molecular forms of cholecystokinin (CCK-39, -33, and -8) were used in concentrations from 10(-11) to 19(-8) mol/l to stimulate the endocrine and exocrine secretion from the isolated perfused porcine pancreas. During perfusion with a glucose concentration of 7.5 mmol/l CCK-39 in the highest concentration increased the insulin secretion slightly. No significant effect was observed at lower glucose concentrations (5.0 and 3.5 mmol/l). CCK-33 and -8 did not stimulate the secretion… CONTINUE READING