Secretory cell hyperplasia and defects in Notch activity in a mouse model of leukocyte adhesion deficiency type II.

@article{Waterhouse2010SecretoryCH,
  title={Secretory cell hyperplasia and defects in Notch activity in a mouse model of leukocyte adhesion deficiency type II.},
  author={Christopher Curtis Matchett Waterhouse and Steven Johnson and Mia Phillipson and Lori Zbytnuik and Bj{\"o}rn Petri and Margaret Kelly and John B. Lowe and Paul Kubes},
  journal={Gastroenterology},
  year={2010},
  volume={138 3},
  pages={1079-90.e1-5}
}
BACKGROUND & AIMS Leukocyte adhesion deficiency II (LAD II) is a rare condition caused by defective protein fucosylation, causing decreased leukocyte rolling, psychomotor retardation, and poor growth. The ligand-binding activity of Notch, a gastrointestinal signaling protein, depends on O-fucosylation. We investigated Notch signaling and intestinal epithelial architecture in a mouse model of LAD II. METHODS Mice lacking 3,5-epimerase/4-reductase (FX) or FX(-/-) bone marrow chimeras (with… CONTINUE READING