Secretory and cytosolic (pro)renin in kidney, heart, and adrenal gland

  title={Secretory and cytosolic (pro)renin in kidney, heart, and adrenal gland},
  author={Joerg Peters},
  journal={Journal of Molecular Medicine},
Renin is commonly known as a secretory glycoprotein, which is expressed, stored, and secreted in a regulated manner by the kidney. The rat kidney exclusively expresses secretory renin. In this organ, renin regulates glomerular filtration rate, vascular resistance, and sodium reabsorbtion. In the adult rat heart, secretory preprorenin is not expressed. Instead, an alternative renin transcript is expressed that encodes for a previously unrecognized cytosolic renin. The expression of cytosolic but… CONTINUE READING