Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype

@inproceedings{Ohanna2013SecretomeFS,
  title={Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype},
  author={Micka{\"e}l Ohanna and Yann Ch{\'e}li and Caroline Bonet and Vanessa F. Bonazzi and Marylin Allegra and Sandy Giuliano and Karine Bille and P Bahadoran and Damien Giacchero and Jean Philippe Lacour and Glen M Boyle and Nicholas Hayward and Corine Bertolotto and Robert Ballotti},
  booktitle={Oncotarget},
  year={2013}
}
Here, we showed that the secretome of senescent melanoma cells drives basal melanoma cells towards a mesenchymal phenotype, with characteristic of stems illustrated by increased level of the prototype genes FN1, SNAIL, OCT4 and NANOG. This molecular reprogramming leads to an increase in the low-MITF and slow-growing cell population endowed with melanoma-initiating cell features. The secretome of senescent melanoma cells induces a panel of 52 genes, involved in cell movement and cell/cell… CONTINUE READING
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