Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells.

@article{Ji2009SecretomebasedPR,
  title={Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells.},
  author={Hong Tai Ji and David W. Greening and Eugene Anthony Kapp and Robert L. Moritz and Richard J. Simpson},
  journal={Proteomics. Clinical applications},
  year={2009},
  volume={3 4},
  pages={433-51}
}
Although experiments in rodents and human population-based studies have demonstrated the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac in colorectal cancer (CRC) prevention, a detailed knowledge of the underlying mechanism of action of this drug is limited. To better understand the chemopreventitive effects of sulindac, especially early sulindac-induced apoptotic events, we used the CRC cell line LIM1215 as an experimental model, focusing on proteins secreted into… CONTINUE READING

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