Secretome and degradome profiling shows that Kallikrein‐related peptidases 4, 5, 6, and 7 induce TGFβ‐1 signaling in ovarian cancer cells

@inproceedings{Shahinian2014SecretomeAD,
  title={Secretome and degradome profiling shows that Kallikrein‐related peptidases 4, 5, 6, and 7 induce TGFβ‐1 signaling in ovarian cancer cells},
  author={Hasmik Shahinian and D Loessner and Martin L. Biniossek and Jayachandran N Kizhakkedathu and Judith Ann Clements and Viktor Magdolen and Oliver Schilling},
  booktitle={Molecular oncology},
  year={2014}
}
Kallikrein-related peptidases, in particular KLK4, 5, 6 and 7 (4-7), often have elevated expression levels in ovarian cancer. In OV-MZ-6 ovarian cancer cells, combined expression of KLK4-7 reduces cell adhesion and increases cell invasion and resistance to paclitaxel. The present work investigates how KLK4-7 shape the secreted proteome ("secretome") and proteolytic profile ("degradome") of ovarian cancer cells. The secretome comparison consistently identified >900 proteins in three replicate… CONTINUE READING

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