Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.

Abstract

With increasing worldwide rates of morbidity and mortality of pulmonary fibrosis, the development of effective therapeutics for this disease is of great interest. Secretoglobin (SCGB) 3A2, a novel cytokine-like molecule predominantly expressed in pulmonary airways epithelium, exhibits anti-inflammatory and growth factor activities. In the current study… (More)
DOI: 10.1074/jbc.M111.239046

Topics

Cite this paper

@article{Kurotani2011Secretoglobin3S, title={Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.}, author={Reiko Kurotani and Satoshi Okumura and Tsutomu Matsubara and Utako Yokoyama and John R. Buckley and Takeshi Tomita and Kyohei Kezuka and Tomokazu Nagano and Dominic Esposito and Troy E. Taylor and William K Gillette and Yoshihiro Ishikawa and Hiroyuki Abe and Jerrold M. Ward and Shioko Kimura}, journal={The Journal of biological chemistry}, year={2011}, volume={286 22}, pages={19682-92} }