Secretion systems in Gram-negative bacteria: structural and mechanistic insights

  title={Secretion systems in Gram-negative bacteria: structural and mechanistic insights},
  author={Tiago R D Costa and C. Felisberto-Rodrigues and Amit Meir and M. Prevost and Adam Redzej and Martina Trokter and G. Waksman},
  journal={Nature Reviews Microbiology},
  • Tiago R D Costa, C. Felisberto-Rodrigues, +4 authors G. Waksman
  • Published 2015
  • Biology, Medicine
  • Nature Reviews Microbiology
  • Bacteria have evolved a remarkable array of sophisticated nanomachines to export various virulence factors across the bacterial cell envelope. In recent years, considerable progress has been made towards elucidating the structural and molecular mechanisms of the six secretion systems (types I–VI) of Gram-negative bacteria, the unique mycobacterial type VII secretion system, the chaperone–usher pathway and the curli secretion machinery. These advances have greatly enhanced our understanding of… CONTINUE READING
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