Secretion profile of human bone marrow stromal cells: donor variability and response to inflammatory stimuli.

@article{Zhukareva2010SecretionPO,
  title={Secretion profile of human bone marrow stromal cells: donor variability and response to inflammatory stimuli.},
  author={Victoria Zhukareva and Maria Obrocka and John D. Houl{\'e} and Itzhak Fischer and Birgit Neuhuber},
  journal={Cytokine},
  year={2010},
  volume={50 3},
  pages={
          317-21
        }
}
Mesenchymal stem cells (MSC) derived from bone marrow are ideal transplants for a variety of CNS disorders and appear to support recovery after injury by secreting therapeutic factors. There is considerable variability in the secretion profile of MSC derived from different donors and it is known that MSC secretion changes in response to inflammatory stimuli, but no comprehensive analysis has been performed to address these issues. Here we show that MSC from seven donors secrete chemokines and… CONTINUE READING
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