Secretion of xenobiotics via multidrug resistance protein (MDR) in kidney: application to development of artificial "hybrid kidney"


This review deals with the functional significance of multidrug resistance protein (MDR) in the renal proximal tubule, and the possible application of MDR to an artificial "hybrid kidney" for the treatment of digoxin intoxication. Rhodamine 123 was used as a fluorescent substrate of MDR to measure the efflux of the drug across the luminal membrane in… (More)
DOI: 10.1007/s101570170001


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