Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

Abstract

Activated ras oncogene transfection into suitable recipient cells has been shown to induce the metastatic phenotype (Thorgeirsson, et al., Mol. Cell. Biol., 5: 259-262, 1985). We have used this model system to study the correlation of basement membrane collagenolysis with metastatic propensity. The c-Ha-ras oncogene alone, or combined with v-myc… (More)

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@article{Garbisa1987SecretionOT, title={Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.}, author={Spiridione Garbisa and Rudy O. Pozzatti and Ruth J. Muschel and Umberto Saffiotti and Marina Ballin and Ronald H. Goldfarb and Greg Khoury and Lance A. Liotta}, journal={Cancer research}, year={1987}, volume={47 6}, pages={1523-8} }