Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease.

@article{Bouma1996SecretionOT,
  title={Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease.},
  author={Gerrit Joan Bouma and J. Bart A. Crusius and Marco Oudkerk Pool and J J Evelien Kolkman and Brigitta Mary E von Blomberg and Piet J. Kostense and M. J. Giphart and Geziena M Th Schreuder and Stephan G. M. Meuwissen and Amado Salvador Pe{\~n}a},
  journal={Scandinavian journal of immunology},
  year={1996},
  volume={43 4},
  pages={456-63}
}
The genes for tumour necrosis factor alpha (TNF alpha) and lymphotoxin alpha (LT alpha; TNF beta) are tandemly arranged in the central region of the MHC. They may, therefore, be of importance for the aetiology of MHC-associated diseases. The authors have prospectively studied the secretion of TNF alpha and LT alpha in relation to polymorphisms at positions -308 and -238 in the TNF alpha gene (TNFA), and two polymorphisms in the first intron of the LT alpha gene (LTA), as well as HLA-DR in 30… CONTINUE READING