Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway

  title={Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway},
  author={Ding Chen and Lei Lei and Chunxue Lu and Rhonda Flores and Matthew P DeLisa and Tucker C. Roberts and Floyd E Romesberg and Guangming Zhong},
The chlamydial protease/proteasome-like activity factor (CPAF) is secreted into the host cytosol to degrade various host factors that benefit chlamydial intracellular survival. Although the full-length CPAF is predicted to contain a putative signal peptide at its N terminus, the secretion pathway of CPAF is still unknown. Here, we have provided experimental evidence that the N-terminal sequence covering the M1-G31 region was cleaved from CPAF during chlamydial infection. The CPAF N-terminal… CONTINUE READING


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