Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor.

@article{Zhao2014SecretionOS,
  title={Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor.},
  author={Hu Zhao and Jifan Feng and Kerstin Seidel and Songtao Shi and Ophir D. Klein and Paul Thomas Sharpe and Yang Chai},
  journal={Cell stem cell},
  year={2014},
  volume={14 2},
  pages={
          160-73
        }
}
View on PubMed
cell.com
224 Citations
Highly Influential Citations
13
Background Citations
85
Methods Citations
4
Results Citations
5

Figures from this paper

224 Citations

Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling

Mesenchymal Stem Cells and Pericytes: To What Extent Are They Related?

The recent evidences that suggest that perivascular MSCs are adventitial cells, acting as precursors of pericytes and other stromal cells during tissue homeostasis are highlighted.

Functional characteristics of dental pulp mesenchymal stem cells

It is demonstrated that the Wnt pathway may play a crucial role in regulating MSCs during incisor injury repair in vitro and in vivo, and the naturally existing “incisal tip niche” is potentially a unique model for new insights into mesenchymal tissue repair in vivo.

Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

A distinct population of MSCs that is maintained by TACs through Dlk1 ligand and that contribute to MTACs and mesenchymal lineages including dental pulp and odontoblasts is described.

Pericytes, integral components of adult hematopoietic stem cell niches

Stem cell properties of Gli1-positive cells in the periodontal ligament.

Dental mesenchymal stem cells

It is shown that Schwann cells on the peripheral nerves in the close proximity to the incisor tooth constitute a stem cell niche and HMGA2, a neural stem cell marker during embryogenesis, is robustly expressed in deciduous pulp cells.

Isolation of Dental Stem Cell-Enriched Populations from Continuously Growing Mouse Incisors.

  • A. Balić
  • Biology
    Methods in molecular biology
  • 2019
This chapter describes the isolation of the Sox2-GFP+ cell population that is highly enriched in ESCs and ways to obtain populations enriched in the incisor MSCs using FACS sorting of antibody-labeled cells.

Gli1+ Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation

Modelling the mesenchymal stem cell niche in vitro using magnetic nanoparticles

This project aimed to develop a novel, bio-responsive in vitro 3D MSC niche model, which adopted the use of magnetic nanoparticle loaded MSCs, which were levitated using an external magnetic field, to form multicellular spheroids which were subsequently located within a Type I collagen gel.
...

References

SHOWING 1-10 OF 65 REFERENCES

Dual origin of mesenchymal stem cells contributing to organ growth and repair

This study identifies a dual origin of MSCs in a single tissue and suggests that the pericyte contribution to MSC-derived mesenchymal cells in any given tissue is variable and possibly dependent on the extent of the vascularity.

A perivascular origin for mesenchymal stem cells in multiple human organs.

The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells.

This work demonstrates the co-existence of 2 separate perivascular MSC progenitors: pericytes in capillaries and microvessels and adventitial cells around larger vessels.

Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling.

Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.

Human adipose tissue is a source of multipotent stem cells.

To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.

Localization of Putative Stem Cells in Dental Epithelium and Their Association with Notch and Fgf Signaling

A model in which FGF signaling from the mesenchyme regulates the Notch pathway in dental epithelial stem cells via stimulation of lunatic fringe expression is presented and has a central role in coupling the mitogenesis and fate decision of stem cells.

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

It is demonstrated that Hh signaling is not required for stem cell survival but is essential for the generation of ameloblasts, one of the major differentiated cell types in the tooth, from the stem cells.

Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts.

A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells

It is concluded that a restricted domain of Shh signaling is localized to the arterial adventitia and may play important roles in maintenance of resident vascular SMC progenitor cells in the artery wall.
...