Secretion of rat hepatic lipase is blocked by inhibition of oligosaccharide processing at the stage of glucosidase I.

@article{Verhoeven1990SecretionOR,
  title={Secretion of rat hepatic lipase is blocked by inhibition of oligosaccharide processing at the stage of glucosidase I.},
  author={Adrie J. M. Verhoeven and Hans Jansen},
  journal={Journal of lipid research},
  year={1990},
  volume={31 10},
  pages={1883-93}
}
Rat hepatic lipase is a glycoprotein bearing two N-linked oligosaccharide chains. The importance of glycosylation in the secretion of hepatic lipase was studied using freshly isolated rat hepatocytes. Various inhibitors of oligosaccharide synthesis and processing were used at concentrations that selectively interfere with protein glycosylation. Secretion of hepatic lipase activity was abolished by tunicamycin, castanospermine, and N-methyldeoxynojirimycin. No evidence was found by ELISA or… CONTINUE READING

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