Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein.

@article{Mller1996SecretionOO,
  title={Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein.},
  author={Marcella C. A. M{\"u}ller and H. W. Roelofsen and Petra Lynen Jansen},
  journal={Seminars in liver disease},
  year={1996},
  volume={16 2},
  pages={
          211-20
        }
}
The canalicular multispecific organic anion transporter (cMOAT) is one of at least four ATP-dependent transport systems identified so far in the canalicular membrane domain. Using mutant rat strains that lack organic anion secretion, the substrate specificity of cMOAT has been characterized. cMOAT appears to be responsible for the elimination of amphipathic anionic conjugates formed by phase II conjugation. Very recently it has been shown that the hepatocyte-specific homologue (MRP2) of the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Similar Papers

Loading similar papers…