Secretion of mouse growth hormone by transduced primary human keratinocytes: prospects for an animal model of cutaneous gene therapy.

Abstract

BACKGROUND Keratinocytes are a very attractive vehicle for ex vivo gene transfer and systemic delivery because proteins secreted by these cells may reach the circulation via a mechanism that mimics the natural process. METHODS An efficient retroviral vector (LXSN) encoding the mouse growth hormone gene (mGH) was used to transduce primary human… (More)
DOI: 10.1002/jgm.1196

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