Secretion of mouse growth hormone by transduced primary human keratinocytes: prospects for an animal model of cutaneous gene therapy.


BACKGROUND Keratinocytes are a very attractive vehicle for ex vivo gene transfer and systemic delivery because proteins secreted by these cells may reach the circulation via a mechanism that mimics the natural process. METHODS An efficient retroviral vector (LXSN) encoding the mouse growth hormone gene (mGH) was used to transduce primary human… (More)
DOI: 10.1002/jgm.1196


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics