Secretion of medullipin I by the kidney involves the cytochrome P-450 enzyme system.

@article{Muirhead1994SecretionOM,
  title={Secretion of medullipin I by the kidney involves the cytochrome P-450 enzyme system.},
  author={E. Muirhead and B. Brooks and L. W. Byers},
  journal={Journal of hypertension},
  year={1994},
  volume={12 2},
  pages={
          155-8
        }
}
OBJECTIVE To determine whether secretion of medullipin I by the kidney is dependent on the cytochrome P-450 enzyme system in Sprague-Dawley and spontaneously hypertensive rats (SHR). METHODS Isolated kidneys from Sprague-Dawley rats were perfused with 5% human albumin gassed with 95% O2 and 5% CO2 at 185 mmHg. The resultant renal venous effluent was tested in the SHR for medullipin I-type vasodepressor activity. The kidneys were then treated with ketoconazole, and inhibitor of the cytochrome… Expand