Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability.

@article{Didier2003SecretionOI,
  title={Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability.},
  author={Nathalie Didier and Ignacio Andres Romero and Christophe A Cr{\'e}minon and Anne Wijkhuisen and J acques Grassi and Alo{\"i}se M Mabondzo},
  journal={Journal of neurochemistry},
  year={2003},
  volume={86 1},
  pages={246-54}
}
Evidence suggests that endothelin-1 (ET-1) plays an essential role in brain inflammation. However, whether ET-1 contributes directly to blood-brain barrier (BBB) breakdown remains to be elucidated. Using an in vitro BBB model consisting of co-cultures of human primary astrocytes and brain microvascular endothelial cells (BMVECs), we first investigated the expression of ET-1 by BMVECs upon stimulation with tumour necrosis factor (TNF)-alpha, which plays an essential role in the induction and… CONTINUE READING

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