Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: regulatory role of platelet-derived growth factor.

@article{Pinzani1990SecretionOI,
  title={Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: regulatory role of platelet-derived growth factor.},
  author={Massimo Pinzani and Hanna E. Abboud and David C. Aron},
  journal={Endocrinology},
  year={1990},
  volume={127 5},
  pages={
          2343-9
        }
}
  • Massimo Pinzani, Hanna E. Abboud, David C. Aron
  • Published in Endocrinology 1990
  • Biology, Medicine
  • Insulin-like growth factor (IGF-I) is synthesized in multiple organs, including the liver, and may play a role in tissue growth and repair. We report that liver fat-storing cells (FSC) secrete IGF-I immunoreactivity in the culture medium. Secretion of IGF-I immunoreactivity was blocked in the presence of cycloheximide, suggesting de novo synthesis. Culture medium conditioned by FSC was concentrated and applied to a Sephadex G100 column equilibrated in a denaturing buffer. Two major species with… CONTINUE READING

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