Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes.

@article{Wickenhauser1995SecretionOC,
  title={Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes.},
  author={Claudia Wickenhauser and Johann Lorenzen and Juergen Thiele and A Hillienhof and K. Jungheim and Beate Schmitz and Martin-Leo Hansmann and Randy H Fischer},
  journal={Blood},
  year={1995},
  volume={85 3},
  pages={685-91}
}
The effects of cytokine stimulation [recombinant human interleukin (rhIL)-1 alpha, rhIL-3, rhIL-6, rhIL-11, and rh granulocyte-macrophage colony-stimulating factor (GM-CSF)] on the secretory activity of normal human megakaryocytes were studied by means of the reverse hemolytic plaque assay (RHPA) in enriched cell preparations. This test facilitates an extremely sensitive determination of cytokine secretion at the single-cell level, together with the clear-cut identification of each… CONTINUE READING

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