Secretion of Sulfonamides in Milk Following Intramammary Oral and Parenteral Administrations

@article{Paar1964SecretionOS,
  title={Secretion of Sulfonamides in Milk Following Intramammary Oral and Parenteral Administrations},
  author={G. Paar and R. Cannon and G. Hawkins},
  journal={Journal of Dairy Science},
  year={1964},
  volume={47},
  pages={251-253}
}
Summary Commercial preparations of sulfonamides were administered to lactating dairy cows by one or more routes to determine the duration of their secretion in milk. Neoprontosil injected intramuscularly at the rate of 240 gr/cow was not detected in milk during the first 24-hr post-injection. Intravenous injection of sulfabrom (0.25 gr/lb of body wt), suljex (772 gr/cow), and sulfamerazine (0.5 and 1.0 gr/lb of body wt) resulted in detectable levels of drug residues for maximum periods of 21… 
3 Citations
Elimination of sulphamerazine in sheep.
TLDR
The mammary excretion of sulphamerazine was examined in ewes given a continuous intravenous infusion and clearance of the non-protein-bound fraction was slightly more or similar to the creatinine clearance, but was influenced by changes in the pH of urine, since clearance was greater in slightly alkaline and less in acidic urine.
Half-life, volume of distribution and acetylation of sulphamerazine in sheep.
  • M. Atef
  • Chemistry, Medicine
    Zentralblatt fur Veterinarmedizin. Reihe A
  • 1978
TLDR
The half-lives indicated the presence of two phases, α and s, of sulphamerazine following oral and intramuscular routes, whereas the distribution phase (α) after intravenous injection was 48 ± 4 minutes and the elimination half-life (s phase) in plasma was 340 ± 8 to 452 ± 10 minutes.
Citrate metabolism in 16 Leuconostoc mesenteroides subsp. mesenteroides and subsp. dextranicum strains
TLDR
Citrate degradation ability was stable for at least 130 generations in 81% of the Leuconostoc strains and the main degradation products resulting from the co-metabolism of citrate and glucose were acetate, lactate and pyruvate.

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Simplified Partition Chromatographic Procedures