Secretion of Protective Antigens by Tissue-Stage Nematode Larvae Revealed by Proteomic Analysis and Vaccination-Induced Sterile Immunity

@inproceedings{Hewitson2013SecretionOP,
  title={Secretion of Protective Antigens by Tissue-Stage Nematode Larvae Revealed by Proteomic Analysis and Vaccination-Induced Sterile Immunity},
  author={James P Hewitson and Alasdair C. Ivens and Yvonne M. Harcus and Kara J. Filbey and Henry J McSorley and Janice Murray and Stephen Bridgett and David A. Ashford and Adam A. Dowle and Rick M. Maizels},
  booktitle={PLoS pathogens},
  year={2013}
}
Gastrointestinal nematode parasites infect over 1 billion humans, with little evidence for generation of sterilising immunity. These helminths are highly adapted to their mammalian host, following a developmental program through successive niches, while effectively down-modulating host immune responsiveness. Larvae of Heligmosomoides polygyrus, for example, encyst in the intestinal submucosa, before emerging as adult worms into the duodenal lumen. Adults release immunomodulatory excretory… CONTINUE READING
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