Secretion of Proinflammatory Eicosanoid-Like Substances Precedes Allergen Release from Pollen Grains in the Initiation of Allergic Sensitization

  title={Secretion of Proinflammatory Eicosanoid-Like Substances Precedes Allergen Release from Pollen Grains in the Initiation of Allergic Sensitization},
  author={H. Behrendt and A. Kasche and C. Ebner von Eschenbach and U. Risse and J. Huss-Marp and J. Ring},
  journal={International Archives of Allergy and Immunology},
  pages={121 - 125}
  • H. Behrendt, A. Kasche, +3 authors J. Ring
  • Published 2001
  • Medicine, Biology
  • International Archives of Allergy and Immunology
  • It is commonly believed that allergic sensitization starts when an allergen contacts the surface of an antigen-presenting cell in mucosal or skin epithelia. Most studies dealing with this aspect use allergen extracts as stimulus. Under natural exposure conditions, however, the bioavailability of allergen depends on allergen liberation from internal binding sites within the allergen carrier, e.g. pollen grains. In comparing total protein and major allergen release from timothy grass (Phleum… CONTINUE READING
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