Secretion of EGF-like domain of heregulinβ promotes axonal growth and functional recovery of injured sciatic nerve.

@article{Joung2010SecretionOE,
  title={Secretion of EGF-like domain of heregulinβ promotes axonal growth and functional recovery of injured sciatic nerve.},
  author={Insil Joung and Minjoo Yoo and Ji Hyoun Woo and Chi Young Chang and Hwon Heo and Yunhee Kim Kwon},
  journal={Molecules and cells},
  year={2010},
  volume={30 5},
  pages={477-84}
}
Neuregulin 1 (NRG1) and epidermal growth factor receptor (ErbB) signaling pathways control Schwann cells during axonal regeneration in an injured peripheral nervous system. We investigated whether a persistent supply of recombinant NRG1 to the injury site could improve axonal growth and recovery of sensory and motor functions in rats during nerve regeneration. We generated a recombinant adenovirus expressing a secreted form of EGF-like domain from Heregulinβ (sHRGβE-Ad). This virus, sHRGβE-Ad… CONTINUE READING