Secretion of DJ-1 into the serum of patients with Parkinson's disease.

  title={Secretion of DJ-1 into the serum of patients with Parkinson's disease.},
  author={Chinatsu Maita and Sachiko Tsuji and Ichiro Yabe and Shinsuke Hamada and Akihiko Ogata and Hiroyhsi Maita and Sanae M. M. Iguchi-Ariga and Hidenao Sasaki and Hiroyoshi Ariga},
  journal={Neuroscience letters},
  volume={431 1},
DJ-1 was initially identified by us as a novel oncogene and has later been found to be a causative gene for familial Parkinson's disease PARK7. DJ-1 plays role in transcriptional regulation and in oxidative stress function, and loss of its function is thought to be related to onset age, mode of progression and clinical severity of both familial and sporadic forms of Parkinson's disease (PD). DJ-1 is localized both in the cytoplasm and nucleus, and it has been reported to be secreted into the… CONTINUE READING

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