Secretion of ATP from Schwann cells through lysosomal exocytosis during Wallerian degeneration.

@article{Shin2012SecretionOA,
  title={Secretion of ATP from Schwann cells through lysosomal exocytosis during Wallerian degeneration.},
  author={Youn Ho Shin and Seo Jin Lee and Junyang Jung},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={429 3-4},
  pages={163-7}
}
The present study demonstrates that adenosine triphosphate (ATP) is released from Schwann cells through lysosomal exocytosis during Wallerian degeneration and in response to stimulation. In primary Schwann cell cultures, ATP was stored in lysosomal vesicles. ATP could then induce Ca(2+)-dependent lysosomal exocytosis. Among three stimulants of lysosomal exocytosis (glutamate, NH(4)Cl and zymosan), only NH(4)Cl was sufficient to induce ATP release from ex vivo sciatic nerve explants at 3 days in… CONTINUE READING

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