Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.

@article{Lee1992SecretionAL,
  title={Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.},
  author={James Joseph Lee and Doris P von Kessler and Sarah L. Parks and Philip A Beachy},
  journal={Cell},
  year={1992},
  volume={71 1},
  pages={
          33-50
        }
}
The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show here that one such gene, hedgehog, encodes a protein targeted to the secretory pathway and is expressed coincidently with engrailed in embryos and in imaginal discs; maintenance of… CONTINUE READING

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