Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man.

@article{Geppetti1988SecretionPA,
  title={Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man.},
  author={Pierangelo Geppetti and Bruno M Fusco and S. Marabini and Carlo A. Maggi and Marcello Fanciullacci and Federigo Sicuteri},
  journal={British journal of pharmacology},
  year={1988},
  volume={93 3},
  pages={509-14}
}
1. Topical application of capsaicin to the human nasal mucosa induced a burning sensation and sneezing. A dose-dependent seromucous nasal secretion was also observed. Capsaicin (75 micrograms) was more potent than methacholine (50 mg) in producing nasal secretion, while topical histamine (200 micrograms), substance P (135 micrograms) and calcitonin gene-related peptide (36 micrograms) did not induce rhinorrhea. 2. Pretreatment with either topical ipratropium bromide, systemic… CONTINUE READING