Corpus ID: 42126315

Secretin inhibits canine gastric acid secretion in response to pentagastrin by modulating gastric histamine release.

@article{Gerber1996SecretinIC,
  title={Secretin inhibits canine gastric acid secretion in response to pentagastrin by modulating gastric histamine release.},
  author={J. Gerber and N. A. Payne},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={279 2},
  pages={
          718-23
        }
}
  • J. Gerber, N. A. Payne
  • Published 1996
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The effect of secretin on pentagastrin- and gastrin-stimulated gastric histamine release and acid secretion was examined in the anesthetized dog model, where all compounds were infused directly into the artery supplying the gastric corpus. Secretin at an infusion rate of 10 ng/kg/min resulted in approximately 90% inhibition of gastric secretion in response to pentagastrin (20 ng/kg/min), whereas at the physiological postprandial concentration of 40 pg/ml it inhibited gastric secretion by… Expand
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