Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes.

@article{Marinelli1999SecretinIT,
  title={Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes.},
  author={R. Marinelli and P. Tietz and L. Pham and L. Rueckert and P. Agre and N. LaRusso},
  journal={The American journal of physiology},
  year={1999},
  volume={276 1},
  pages={
          G280-6
        }
}
Aquaporin-1 (AQP1) water channels are present in the apical and basolateral plasma membrane domains of bile duct epithelial cells, or cholangiocytes, and mediate the transport of water in these cells. We previously reported that secretin, a hormone known to stimulate ductal bile secretion, increases cholangiocyte osmotic water permeability and stimulates the redistribution of AQP1 from an intracellular vesicular pool to the cholangiocyte plasma membrane. Nevertheless, the target plasma membrane… Expand