Secretin causes H+/HCO3- secretion from pig pancreatic ductules by vacuolar-type H(+)-adenosine triphosphatase.

@article{Villanger1995SecretinCH,
  title={Secretin causes H+/HCO3- secretion from pig pancreatic ductules by vacuolar-type H(+)-adenosine triphosphatase.},
  author={Olaug Villanger and T Veel and Morten G Raeder},
  journal={Gastroenterology},
  year={1995},
  volume={108 3},
  pages={850-9}
}
BACKGROUND/AIMS Secretin stimulates pancreatic ductules to secrete HCO3- into pancreatic juice and H+ into interstitial fluid. The aim of the present study was first to examine whether ductular H+ secretion is inhibited by micromolar concentrations of bafilomycin A1, which blocks vacuolar H(+)-adenosine triphosphatase by specific action, and secondly to test for evidence of ductular Na+/HCO3- cotransport. METHODS Ductular H+ secretion was estimated from the rate of intracellular pH recovery… CONTINUE READING
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