Secretin and its C-terminal hexapeptide potentiates insulin release in mouse islets.

@article{Kofod1986SecretinAI,
  title={Secretin and its C-terminal hexapeptide potentiates insulin release in mouse islets.},
  author={Hans Kofod and Birtha Hansen and {\AA}ke Lernmark and Carl J\orgen Hedeskov},
  journal={The American journal of physiology},
  year={1986},
  volume={250 2 Pt 1},
  pages={E107-13}
}
Peptides representing the C-terminal end of secretin were synthetized and their effects tested along with secretin on column-perifused isolated mouse pancreatic islets. Insulin release induced by 10 mmol/l D-glucose was potentiated by secretin tested in a concentration range of 0.01-10 micrograms/ml; the maximal effect was obtained with 1 microgram/ml… CONTINUE READING