Corpus ID: 9641860

Secretin and Autism : A Clue But Not a Cure

  title={Secretin and Autism : A Clue But Not a Cure},
  author={C. Schutt}
he world of autism has been shaken by NBC's broadcast on Dateline of a film segment documenting the effect of secretin on restoring speech and sociability to autistic children. At first blush, it seems unlikely that an intestinal hormone regulating bicarbonate levels in the stomach in response to a good meal might influence the language centers of the brain so profoundly. However, recent discoveries in neurobiology suggest several ways of thinking about the secretin-autism connection that could… Expand
Effect of secretin on children with autism: a randomized controlled trial
The results are consistent with a systematic review of randomized controlled trials evaluating the effect of secretin in children with autism. Expand
Children with autistic spectrum disorders. I: Comparison of placebo and single dose of human synthetic secretin
A single dose of intravenous human secretin is not effective in changing behaviour and communication in children with ASD when compared to placebo. Expand
Novel treatments for autistic spectrum disorders.
  • S. Levy, S. Hyman
  • Medicine
  • Mental retardation and developmental disabilities research reviews
  • 2005
Secretin as a therapy for autism is discussed as an example of how a clinical observation rapidly grew to a widespread treatment before well-designed studies demonstrated absence of effect. Expand


The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
A hypothalamus-specific mRNA is described that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin, suggesting that the hypocretins function within the CNS as neurotransmitters. Expand
Vasoactive intestinal peptide downregulates the expression of IL-2 but not of IFNγ from stimulated murine T lymphocytes
The neuropeptide vasoactive intestinal peptide (VIP) was reported to inhibit T cell proliferation and induced a rapid increase in intracellular cAMP in CD4+ T cells, suggesting that the inhibitory effect of VIP could be mediated through the induction of cAMP. Expand
Similar involvement of VIP receptor type I and type II in lymphocyte chemotaxis
Chemotactic effects of VIP and related agonists with different affinities for VIP- and peptide histidine-isoleucine (PHI)-related receptors are studied to suggest that VIPR1 activation can stimulate normal T and B cell chemotaxis. Expand
The Second Brain Secretin and Vasoactive Intestinal Peptide Receptors: Members of a Unique Family of G Protein-Coupled Receptors
  • Gastro-enterology
  • 1998