Secretin‐induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways

@article{Lu2009SecretininducedGR,
  title={Secretin‐induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways},
  author={Y. Lu and C. Owyang},
  journal={Neurogastroenterology \& Motility},
  year={2009},
  volume={21}
}
  • Y. Lu, C. Owyang
  • Published 2009
  • Chemistry, Medicine
  • Neurogastroenterology & Motility
Abstract  Secretin has been shown to delay gastric emptying and inhibit gastric motility. We have demonstrated that secretin acts on the afferent vagal pathway to induce gastric relaxation in the rat. However, the efferent pathway that mediates the action of secretin on gastric motility remains unknown. We recorded the response of intragastric pressure to graded doses of secretin administered intravenously to anaesthetized rats using a balloon attached to a catheter and placed in the body of… Expand
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