Secreted virulence factors and immune evasion in visceral leishmaniasis.

Abstract

Evasion or subversion of host immune responses is a well-established paradigm in infection with visceralizing leishmania. In this review, we summarize current findings supporting a model in which leishmania target host regulatory molecules and pathways, such as the PTP SHP-1 and the PI3K/Akt signaling cascade, to prevent effective macrophage activation… (More)
DOI: 10.1189/jlb.0611326

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@article{Lambertz2012SecretedVF, title={Secreted virulence factors and immune evasion in visceral leishmaniasis.}, author={Ulrike Lambertz and Judith Maxwell Silverman and Devki Nandan and W. Robert McMaster and Joachim Clos and Leonard J. Foster and Neil E. Reiner}, journal={Journal of leukocyte biology}, year={2012}, volume={91 6}, pages={887-99} }